农科机构知识库联盟

The Multigene Family Genes-Encoded Proteins of African Swine Fever Virus: Roles in Evolution, Cell Tropism, Immune Evasion, and Pathogenesis

文献类型：外文期刊

第一作者： Huang, Ruojia

作者： Huang, Ruojia;Luo, Rui;Lan, Jing;Lu, Zhanhao;Qiu, Hua-Ji;Wang, Tao;Sun, Yuan

作者机构：

关键词： African swine fever virus; multigene family genes; virulence-associated factors; immunomodulatory factors; cell tropism; immune evasion; vaccines; pathogenesis

期刊名称：VIRUSES-BASEL （影响因子：3.5；五年影响因子：3.7 ）

ISSN：

年卷期： 2025 年 17 卷 6 期

页码：

收录情况： SCI

摘要： African swine fever virus (ASFV), the causative agent of African swine fever (ASF), poses a catastrophic threat to global swine industries through its capacity for immune subversion and rapid evolution. Multigene family genes (MGFs)-encoded proteins serve as molecular hubs governing viral evolution, immune evasion, cell tropism, and disease pathogenesis. This review synthesizes structural and functional evidence demonstrating that MGFs-encoded proteins suppress both interferon signaling and inflammasome activation, while their genomic plasticity in variable terminal regions drives strain diversification and adaptation. Translationally, targeted deletion of immunomodulatory MGFs enables the rational design of live attenuated vaccines that improve protective efficacy while minimizing residual virulence. Moreover, hypervariable MGFs provide strain-specific signatures for PCR-based diagnostics and phylogeographic tracking, directly addressing outbreak surveillance challenges. By unifying virology with translational innovation, this review establishes MGFs as priority targets for next-generation ASF countermeasures.

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