Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae

文献类型： 外文期刊

第一作者： Akone, Sergi Herve

作者： Akone, Sergi Herve;Liu, Zhen;Kalscheuer, Rainer;Proksch, Peter;Akone, Sergi Herve;Mouelle, Eitel Ngoh Misse;Koliye, Pierre Roger;Akone, Sergi Herve;Akone, Sergi Herve;Wang, Hao;Mandi, Attila;Kurtan, Tibor;Hartmann, Rudolf;Bhatia, Sanil;Yang, Jing;Muller, Werner E. G.;Lai, Daowan

作者机构：

关键词： Pseudopestalotiopsis theae; Amphisphaeriaceae; Endophytic fungus; Sulfur-containing xanthone; Meroterpenoids; Cytotoxicity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.004； 五年影响因子：4.129 ）

ISSN： 0031-9422

年卷期： 2022 年 197 卷

页码：

收录情况： SCI

摘要： Chemical investigation of the fungal endophyte Pseudopestalotiopsis theae isolated from leaves of Caloncoba welwitschii, collected in Cameroon, resulted in two previously undescribed sulfur-containing xanthone derivatives sydoxanthones D and E, in addition to three previously undescribed monomeric diisoprenyl-cyclohexene-type meroterpenoids biscognienynes D-F and five known natural products. The structures of the undescribed compounds were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis. Mosher's reaction was performed to determine the absolute configuration of sydoxanthones D and E while TDDFT-ECD calculations were used to assign the configuration of biscognienyne D. Biscognienynes B and D showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with IC50 values of 7.7 and 6.7 mu M and against the human leukemic cell lines HL60, and Hal-01 with IC50 values ranging from 4.3 to 12.1 mu M.

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