The Effect of the Antimicrobial Peptide Plectasin on the Growth Performance, Intestinal Health, and Immune Function of Yellow-Feathered Chickens

文献类型： 外文期刊

第一作者： Zhang, Xinheng

作者： Zhang, Xinheng;Zhao, Qiqi;Wu, Che;Yao, Ziqi;Li, Ruoying;Chen, Liyi;Chen, Feiyang;Xie, Zi;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Zhao, Qiqi;Yao, Ziqi;Li, Ruoying;Chen, Liyi;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Zhao, Qiqi;Yao, Ziqi;Li, Ruoying;Chen, Liyi;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Zhao, Qiqi;Yao, Ziqi;Li, Ruoying;Chen, Liyi;Xie, Zi;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Zhao, Qiqi;Wu, Che;Yao, Ziqi;Li, Ruoying;Chen, Liyi;Chen, Feiyang;Xie, Zi;Chen, Feng;Xie, Qingmei;Wen, Lijun;Yan, Zhuanqiang

作者机构：

关键词： plectasin; performance; immune; intestinal health; yellow-feathered chickens

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.412； 五年影响因子：3.588 ）

ISSN：

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： The goal of the study was to test the effects of an antibiotic substitute, plectasin, on the growth performance, immune function, intestinal morphology and structure, intestinal microflora, ileal mucosal layer construction and tight junctions, ileal immune-related cytokines, and blood biochemical indices of yellow-feathered chickens. A total of 1,500 one-day-old yellow-feathered chicks were randomly divided into four dietary treatment groups with five replicates in each group and 75 yellow-feathered chicks in each replication, as follows: basal diet (group A); basal diet supplemented with 10 mg enramycin/kg of diet (group B), basal diet supplemented with 100 mg plectasin/kg of diet (group C), and basal diet supplemented with 200 mg plectasin/kg of diet (group D). It was found that the dietary antimicrobial peptide plectasin could improve the ADG and had better F/G for the overall period of 1-63 days. Dietary plectasin can enhance H9N2 avian influenza virus (AIV) and Newcastle disease virus (NDV) antibody levels of yellow-feathered chickens at 21, and 35 days of age. Dietary plectasin can enhance the intestine structure, inhibit Escherichia coli and proinflammatory cytokines in the ileum, and ameliorate the blood biochemical indices of yellow-feathered chickens at 21 days of age. This study indicates that the antimicrobial peptide plectasin has beneficial effects on the growth performance, intestinal health and immune function of yellow-feathered chickens.

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