Developments in Negative-Strand RNA Virus Reverse Genetics

文献类型： 外文期刊

第一作者： Wang, Mengyi

作者： Wang, Mengyi;Wu, Jinyan;Cao, Xiaoan;Xu, Long;Wu, Junhuang;Ding, Haiyan;Shang, Youjun;Wang, Mengyi;Wu, Jinyan;Cao, Xiaoan;Xu, Long;Wu, Junhuang;Ding, Haiyan;Shang, Youjun

作者机构：

关键词： negative-strand RNA viruses; reverse genetics; influenza A virus; Ebola virus; peste des petits ruminants virus

期刊名称：MICROORGANISMS （ 影响因子：4.5； 五年影响因子：4.8 ）

ISSN：

年卷期： 2024 年 12 卷 3 期

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收录情况： SCI

摘要： Many epidemics are caused by negative-stranded RNA viruses, leading to serious disease outbreaks that threaten human life and health. These viruses also have a significant impact on animal husbandry, resulting in substantial economic losses and jeopardizing global food security and the sustainable livelihoods of farmers. However, the pathogenic and infection mechanism of most negative-stranded RNA viruses remain unclear. Reverse genetics systems are the most powerful tools for studying viral protein function, viral gene expression regulation, viral pathogenesis, and the generation of engineered vaccines. The reverse genetics of some negative-strand viruses have been successfully constructed, while others have not. In this review, we focus on representative viruses from the Orthomyxoviridae family (IAV), the Filoviridae family (EBOV), and the Paramyxoviridae family (PPRV) to compile and summarize the existing knowledge on reverse genetics techniques for negative-strand viruses. This will provide a theoretical foundation for developing reverse genetics techniques for some negative-strand viruses.

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