Pyridoxal phosphate promotes the γ-aminobutyric acid accumulation, antioxidant and anti-hypertensive activity of germinated tartary buckwheat

文献类型： 外文期刊

第一作者： Yan, Huiling

作者： Yan, Huiling;Chen, Hongxu;Yao, Tian;Xia, Mengying;Liao, Qingxia;Huang, Ludong;Li, Wanjie;Song, Yu;Peng, Lianxin;Zhao, Jianglin;Zou, Liang;Zhao, Gang;Liu, Juan

作者机构：

关键词： Glutamate; GABA shunt; Antioxidant; Anti-hypertensive

期刊名称：JOURNAL OF CEREAL SCIENCE （ 影响因子：3.7； 五年影响因子：4.3 ）

ISSN： 0733-5210

年卷期： 2024 年 120 卷

页码：

收录情况： SCI

摘要： gamma-Aminobutyric acid (GABA), a main inhibitory neurotransmitter, is essential for various biofunctions but is inadequately synthesized by the body. Tartary buckwheat (TB), with its medicinal and culinary uses, is a potential GABA source, yet its natural GABA content is low. Herein, the application of pyridoxal phosphate (PLP) led to a significant increase in GABA content, reaching 3.82 g kg(-1) in PLP-treated germinated TB (PLP-GTB), which is a 9.67-fold increase compared to ungerminated TB (UTB). This elevation in GABA was associated with the activation of glutamate decarboxylase (GAD), an increase in the substrate glutamate (Glu), and the up-regulation of key gene expression (GAD, GS1/2 and GOGAT). Furthermore, PLP-GTB displayed the strongest inhibitory effect on angiotensin-converting enzyme (ACE) activity and exhibited the highest levels of DPPH and ABTS radical scavenging capabilities. Collectively, our findings present a strategy for GABA enrichment in TB, potentially enhancing its anti-hypertensive and antioxidant properties.

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