Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections

文献类型： 外文期刊

第一作者： Li, Ming

作者： Li, Ming;Wang, Zhenglei;Qiu, Yawei;Fu, Shaodong;Xu, Yuanyuan;Miao, Jinfeng;Han, Xiangan;Phouthapane, Vanhnaseng

作者机构：

关键词： Mastitis; S. uberis; Taurine; Blood-milk barrier; NF-kappa B; MAPK

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：5.714； 五年影响因子：5.596 ）

ISSN： 1567-5769

年卷期： 2021 年 101 卷

页码：

收录情况： SCI

摘要： Streptococcus uberis (S. uberis) is an important causative agent of mastitis, leading to significant economic losses to dairy industry. This research used a mouse mastitis model to investigate the protective effects of taurine on mammary inflammatory response and blood-milk barrier integrity in S. uberis challenge. The results showed that taurine attenuated S. uberis-induced mammary histopathological changes, especially neutrophil infiltration. The S. uberis-induced expression of pro-inflammatory mediators were decreased significantly by taurine. Further, we demonstrated that taurine limited the S. uberis-induced inflammatory responses via inhibiting the activation of NF-kappa B and MAPK signaling pathways. Inflammation usually disrupts the mammary barrier system. The recovery of claudin-3 and occludin expressions indicated that attenuation of inflammatory response by taurine can protect the integrity of blood-milk barrier in S. uberis infection. Taken together, our results reveal that the development of taurine as an effective prevention and control strategy for S. uberis-induced mastitis.

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