Human genetic history on the Tibetan Plateau in the past 5100 years

文献类型： 外文期刊

第一作者： Wang, Hongru

作者： Wang, Hongru;Yang, Melinda A.;Ding, Manyu;Cao, Peng;Dai, Qingyan;Liu, Feng;Feng, Xiaotian;Wang, Tianyi;Yang, Ruowei;Ping, Wanjing;Zhang, Zhaoxia;Ko, Albert Min-Shan;Gao, Xing;Fu, Qiaomei;Yang, Melinda A.;Wangdue, Shargan;Li, Linhui;Tsring, Tinley;He, Wei;Tashi, Norbu;Yang, Tsho;Tong, Yan;Chen, Zujun;Lu, Hongliang;Yuan, Haibing;Li, Shuai;Yang, Feng;He, Yuanhong;Lu, Hongliang;Yuan, Haibing;Li, Shuai;Yang, Feng;He, Yuanhong;Chen, Honghai;Zhang, Ming;Dong, Guanghui;Ding, Manyu;Wang, Tianyi;Gao, Xing;Fu, Qiaomei;Wu, Xiaohong;Gao, Yang;Xu, Shuhua;Gao, Yang;Wang, Xiaoji;Zhang, Chao;Yuan, Kai;Xu, Shuhua;Aldenderfer, Mark;Xu, Shuhua;Xu, Shuhua;Xu, Shuhua;Fu, Qiaomei;Wang, Hongru

作者机构：

期刊名称：SCIENCE ADVANCES （ 影响因子：13.6； 五年影响因子：15.4 ）

ISSN： 2375-2548

年卷期： 2023 年 9 卷 11 期

页码：

收录情况： SCI

摘要： Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past similar to 700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.

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