Asperphenalenones Isolated from the Biocontrol Agent Clonostachys rosea and Their Antimicrobial Activities

文献类型： 外文期刊

第一作者： Wang, Lin

作者： Wang, Lin;Kiffe-Delf, Anna-Lene;Simons, Viktor Emanuel;He, Di;Gao, Ying;van Geelen, Lasse;Kalscheuer, Rainer;Ostermann, Philipp Niklas;Schaal, Heiner;Dai, Hao-Fu;Zhao, You-Xing;Mandi, Attila;Kiraly, Sandor Balazs;Kurtan, Tibor;Liu, Zhen

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关键词： Clonostachys rosea; asperphenalenones; antibacterial activity; methicillin-resistant Staphylococcus aureus (MRSA); anti-HIV activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 29 期

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收录情况： SCI

摘要： Clonostachys rosea isa fungus widelydistributed on Earth and has a high capacity to adapt to complex environmentsin soil, plants, or sea. It is an endophyte that can be used as apotential biocontrol agent to protect plants from pathogenic fungi,nematodes, and insects. However, the spectrum of secondary metabolitesproduced by C. rosea has only scarcelybeen studied. In the present study, eight new phenalenones, asperphenalenonesF-M (1-8), together with twoknown derivatives, asperphenalenones E and B (9 and 10), were isolated from the axenic rice culture of this fungus.The structures of the new compounds were elucidated by nuclear magneticresonance, high-resolution electrospray ionization mass spectrometry,electronic circular dichroism, and gas chromatography-massspectrometry analyses. Asperphenalenones J-M (5-8) are unusual phenalenone adducts that areconjugated to diterpenoid glycosides. Asperphenalenones F and H showedmoderate antibacterial activity against methicillin-resistant Staphylococcus aureus, with minimal inhibitory concentrationsof 12.5 and 25 & mu;M, respectively. Asperphenalenone B exhibitedlow antiviral activity against the human immunodeficiency virus replication.Furthermore, asperphenalenones F and H exhibited low cytotoxicityagainst Jurkat cells, while all other compounds were devoid of cytotoxicity.

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