Development of a biocompatible green drug release system using salidroside-TiO2-doped chitosan oligosaccharide molecularly imprinted polymers

文献类型： 外文期刊

第一作者： Liu, Zijie

作者： Liu, Zijie;Ma, Xingbin;Li, Shuyu;Qiu, Jiajie;Liu, Siyu;Huang, Zhifeng;Lin, Hongling;Abd El-Aty, A. M.;Abd El-Aty, A. M.;Abd El-Aty, A. M.

作者机构：

关键词： Surface molecularly; imprinted polymer; Novel functional monomer; Diethylene glycol; Sustained release; Salidroside; dimethacrylate

期刊名称：ARABIAN JOURNAL OF CHEMISTRY （ 影响因子：6.0； 五年影响因子：5.9 ）

ISSN： 1878-5352

年卷期： 2023 年 16 卷 10 期

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收录情况： SCI

摘要： This study focuses on creating a green drug release system using a food-grade titanium dioxide (TiO2) material through surface molecular imprinting. Salidroside (SD) was chosen as the template molecule to synthesize molecularly imprinted polymers (SDT-MIP) utilizing TiO2-doped chitosan oligosaccharides as the functional monomer. The SDT-MIPs were characterized using multiple techniques, and their effectiveness was evaluated through an in vitro release study. Additionally, the affinity of SDT-MIPs toward the template molecule was examined using Langmuir and Freundlich adsorption models. The Langmuir model revealed a maximum capacity of 170.41 mg/g and an imprinted factor of 3.4. The study demonstrated that drug release from the SDT-MIPs in simulated gastrointestinal fluid primarily occurred through pure Fick diffusion. The release kinetics exhibited diffusion coefficients ranging from 3.38 x 10-3 cm2/s to 2.78 x 10-2 cm2/s, indicating their biocompatibility and potential application in drug delivery. Furthermore, the SDT-MIP demonstrated no adverse impact on cell viability even at concentrations as high as 1000 lg/mL. The survival rate of cells cultivated in the presence of SDT-MIP solution exceeded 120 & PLUSMN; 12.46%,

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