Investigation into Antioxidant Mechanism of Lycium barbarum Extract in Carbendazim-Induced PC12 Cell Injury Model through Transcriptomics and Metabolomics Analyses
文献类型： 外文期刊
第一作者： Liu, Pingxiang
作者： Liu, Pingxiang;Chen, Ju;Wen, Xing;Yin, Xiaoqian;Qian, Yongzhong;Xu, Yanyang;Liu, Pingxiang;Chen, Ju;Wen, Xing;Yu, Jiang;Shi, Xin;Gou, Chunlin
作者机构：
关键词： Lycium barbarum L.; antioxidant activity; CBZ-induced injury; transcriptomics; metabolomics
期刊名称：FOODS （ 影响因子：4.7； 五年影响因子：5.1 ）
ISSN：
年卷期： 2024 年 13 卷 15 期
页码：
收录情况： SCI
摘要： Lycium barbarum L., an important functional food in China, has antioxidant and antiaging activity. However, the exact antioxidant activity mechanism of Lycium barbarum extracts (LBE) is not well understood. Therefore, a carbendazim (CBZ)-induced PC12 cell injury model was constructed and vitrificated to study the antioxidant activity of fresh LBE on the basis of extraction parameter optimization via the full factorial design of experiments (DOE) method. The results showed that the pretreatment of PC12 cells with LBE could reduce the reactive oxygen species (ROS) level by 14.6% and inhibited the mitochondrial membrane potential (MMP) decline by 12.0%. Furthermore, the integrated analysis revealed that LBE played an antioxidant role by activating oxidative phosphorylation (OXPHOS) and restoring MMP, maintaining the tricarboxylic acid (TCA) cycle stability, and regulating the GSH metabolic pathway. The results of the present study provide new ideas for the understanding of the antioxidant function of LBE from a global perspective.
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