Subchronic toxicity of oral deltamethrin in laying chickens

文献类型: 外文期刊

第一作者: Liu, Yiming

作者: Liu, Yiming;Han, Mingyue;Liu, Chunshuang;Tang, Yaoxin;Chen, Xiaojie;Liu, Yiming;Han, Mingyue;Liu, Chunshuang;Tang, Yaoxin;Chen, Xiaojie;Gu, Xu;Jia, Ming;Liang, Haijun;Gao, Yunfeng

作者机构: Chinese Acad Agr Sci, Feed Res Inst, Key Lab Anim Antimicrobial Resistance Surveillance, Minist Agr & Rural Affairs, Beijing, Peoples R China;Chinese Acad Agr Sci, Feed Res Inst, Lab Qual Safety Risk Assessment Prod Feed Origin R, Beijing, Peoples R China;China Feed Ind Assoc, Beijing, Peoples R China;Heilingjiang Tech Appraisal Stn Agr Prod Vet Pharm, Harbin, Peoples R China

关键词: deltamethrin; laying chickens; subchronic toxicity; relative organ weight; blood biochemical indexes; pathology

期刊名称:FRONTIERS IN VETERINARY SCIENCE ( 2021影响因子:3.471; 五年影响因子:3.821 )

ISSN:

年卷期: 2022 年 9 卷

页码:

收录情况: SCI

摘要: Pyrethroid pesticides, with low toxicity to birds and mammals and short persistence in the environment, are widely used now. With the development of intensive poultry farming, pesticide application leads to residues in poultry products and pollution in ecological environment. The aim of the present study was to examine deltamethrin subchronic toxicity in laying chickens. One hundred and twelve laying chickens were randomly assigned to 14 groups including 13 groups medicated with deltamethrin (n = 8) and one unmedicated group used as control (n = 8). Tissue samples were collected during and after administration for weighing and histopathological analysis. A single dose of deltamethrin (20 mg center dot kg(-1)center dot BW center dot d) was administered orally to laying chickens for 14 days. The results showed that deltamethrin has no significant effect on the relative organ weight of laying chickens (p > 0.05). The activities of aspartate aminotransferase and cholinesterase in the plasma gradually decreased over time in the medicated group (p < 0.05). Plasma concentrations of urea nitrogen, uric acid, cholesterol, triglycerides, and creatinine significantly increased during treatment (p < 0.05), and significant liver damage and loss of intestinal villous epithelium were observed. The intestinal wall thickness, villus height, and crypt depth of laying chickens were altered by deltamethrin treatment. During treatment was withdrawn, the intestinal repair was more extensive than the liver repair.

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