Identification and Functional Characterization of Tyrosine Decarboxylase from Rehmannia glutinosa

文献类型： 外文期刊

第一作者： Li, Yuanjun

作者： Li, Yuanjun;Wang, Yanan;An, Na;Zheng, Xiaoke;Huang, Longyu;Chen, Chunrong

作者机构：

关键词： Rehmannia glutinosa; acteoside; tyrosine decarboxylase

期刊名称：MOLECULES （ 影响因子：4.927； 五年影响因子：5.11 ）

ISSN：

年卷期： 2022 年 27 卷 5 期

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收录情况： SCI

摘要： Rehmannia glutinosa is an important medicinal plant that has long been used in Chinese traditional medicine. Acteoside, one of the bioactive components from R. glutinosa, possessed various pharmacological activities for human health; however, the molecular mechanism of acteoside formation is not fully understood. In the current study, a novel tyrosine decarboxylase (designated as RgTyDC2) was identified from the R. glutinosa transcriptome. Biochemical analysis of RgTyDC2 showed RgTyDC2 uses tyrosine and dopa as the substrate to produce tyramine and dopamine, respectively, and it displays higher catalytic efficiency toward tyrosine than dopa. Moreover, the transcript level of RgTyDC2 was consistent with the accumulation pattern of acteoside in R. glutinosa, supporting its possible role in the biosynthesis of acteoside in vivo.

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