Replication, pathogenicity, and transmission of SARS-CoV-2 in minks

文献类型： 外文期刊

第一作者： Shuai, Lei

作者： Shuai, Lei;Zhong, Gongxun;Wen, Zhiyuan;Wang, Chong;He, Xijun;Liu, Renqiang;Wang, Jinliang;Shi, Jianzhong;Chen, Hualan;Bu, Zhigao;Shuai, Lei;Zhong, Gongxun;Wen, Zhiyuan;He, Xijun;Liu, Renqiang;Wang, Jinliang;Guan, Yuntao;Bu, Zhigao;Yuan, Quan;Zhao, Qinjian;Xia, Ningshao;Liu, Yuxiu;Huo, Ningning;Deng, Junhua;Bai, Jingjing;Wu, Hongchao;Tian, Kegong

作者机构：

关键词： SARS-CoV-2; mink; replication; pathogenicity; transmission; animal model

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.275； 五年影响因子：17.584 ）

ISSN： 2095-5138

年卷期： 2021 年 8 卷 3 期

页码：

收录情况： SCI

摘要： Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts, and transmits efficiently in minks via respiratory droplets; pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19. We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks. Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.

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[1]Replication, pathogenicity, and transmission of SARS-CoV-2 in minks. Shuai, Lei,Zhong, Gongxun,Wen, Zhiyuan,Wang, Chong,He, Xijun,Liu, Renqiang,Wang, Jinliang,Shi, Jianzhong,Chen, Hualan,Bu, Zhigao,Shuai, Lei,Zhong, Gongxun,Wen, Zhiyuan,He, Xijun,Liu, Renqiang,Wang, Jinliang,Guan, Yuntao,Bu, Zhigao,Yuan, Quan,Zhao, Qinjian,Xia, Ningshao,Liu, Yuxiu,Huo, Ningning,Deng, Junhua,Bai, Jingjing,Wu, Hongchao,Tian, Kegong. 2021

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