Metabolomics fingerprint of three Clematis L. species by UPLC-MS/MS for geographical and varietal classification

文献类型： 外文期刊

第一作者： Dong, Yanjie

作者： Dong, Yanjie;Wu, Yuanjuan;Wang, Wenbo;Wang, Lei;Sun, Chenxi;Dong, Yanjie;Wu, Yuanjuan;Wang, Wenbo;Wang, Lei;Sun, Chenxi;Sun, Chenxi;Ren, Qidong

作者机构：

关键词： Clematis intricate; Clematidis Radix et Rhizoma; Untargeted metabolomics; UPLC-MS/MS

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：6.2； 五年影响因子：6.2 ）

ISSN： 0926-6690

年卷期： 2025 年 234 卷

页码：

收录情况： SCI

摘要： Clematis L. is a genus with global distribution and significant usage in traditional Chinese medicine. Traditionally, species authentication for Clematis L. has relied on morphological characteristics, but such method is susceptible to errors and lacks reproducibility. In this study, an untargeted UPLC-MS/MS-based metabolomics approach was employed to comprehensively discriminate Clematis tangutica (Maxim.) Korsh, C. intricata and Clematidis Radix et Rhizoma (CRR) from eight provinces in China. 2331 differential metabolites were identified by principal components analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA), which revealed distinct separations among the studied regions. The KEGG metabolic pathway analysis showed that flavone and flavonol biosynthesis and flavonoid biosynthesis were closely associated with geographical origin. This work established the metabolomics evidence that flavonoid biosynthesis serves as a biochemical signature of geographical adaptation in Clematis, providing a scientific foundation for precise origin traceability, resource conservation, and quality standardization of medicinal species in traditional Chinese medicine.

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