Dietary Flavonoid Quercetin Supplement Promotes Antiviral Innate Responses Against Vesicular Stomatitis Virus Infection by Reshaping the Bacteriome and Host Metabolome in Mice

文献类型： 外文期刊

第一作者： Li, Tingting

作者： Li, Tingting;Zhu, Jinfeng;Zhu, Yinrui;Pei, Pei;Yang, Kai;Hu, Lin;Li, Tingting;Zhu, Jinfeng;Zhu, Yinrui;Pei, Pei;Yang, Kai;Hu, Lin;Li, Tingting;Wu, Chao;Chen, Nannan;Zhu, Jinfeng;Yu, Qifeng;Zheng, Xing;Wang, Kai

作者机构：

关键词： gut microbiota; metabolomics; pro-inflammatory cytokines; quercetin; vesicular stomatitis virus

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN： 1613-4125

年卷期： 2024 年

页码：

收录情况： SCI

摘要： ScopeActive ingredients in functional foods exhibit broad-spectrum antiviral activity. The objective of this study is to investigate the protective effect of quercetin derived from bee propolis, a natural product with antiviral activity and modulating effects on the gut microbiota, against vesicular stomatitis virus (VSV) infection.Methods and resultsThrough a cellular-based study, this study demonstrates that quercetin can modulate the activity of interferon-regulating factor 3 (IRF3). In vivo, it shows that quercetin protects mice from VSV infection by enhancing interferon production and inhibiting the production of proinflammatory cytokines. The study conducts 16S rRNA-based gut microbiota and nontargets metabolomics analyses to elucidate the mechanisms underlying quercetin-mediated bidirectional communication between the gut microbiome and host metabolome during viral infection. Quercetin not only ameliorates VSV-induced dysbiosis of the intestinal flora but also alters serum metabolites related to lipid metabolism. Cross-correlations between the gut bacteriome and the serum metabolome indicate that quercetin can modulate phosphatidylcholine (16:0/0:0) and 5-acetylamino-6-formylamino-3-methyluracil to prevent VSV infection.ConclusionThis study systematically elucidates the anti-VSV mechanism of quercetin through gut bacteriome and host metabolome assays, offering new insights into VSV treatment and revealing the mechanisms behind a novel disease management strategy using dietary flavonoid supplements. In a study using vesicular stomatitis virus (VSV) as a model, this study evaluates six propolis-derived flavonoids: quercetin, kaempferol, galangin, pinocembrin, apigenin, and chrysin. Quercetin activates the host's innate immunity by modulating gut microbiota and metabolism, promoting interferon production, and suppressing proinflammatory cytokines, effectively protecting mice from VSV infection. image

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