Metabolites and metabolic pathway analysis of sulfadimidine in carp (Cyprinus carpio) based on UHPLC-Q-orbitrap HRMS

文献类型： 外文期刊

第一作者： Wang, Shuwen

作者： Wang, Shuwen;Xing, Lihong;Sun, Xiaojie;Li, Zhaoxin;Ding, Tao;Wang, Jiyao;Peng, Jixing;Ma, Haijian;Lin, Ting;Yang, Qingli

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关键词： Sulfadimidine; Cyprinus carpio; UHPLC-Q-exactive plus orbitrap-MS; Metabolites; Metabolic pathways

期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：8.3； 五年影响因子：8.2 ）

ISSN： 0013-9351

年卷期： 2024 年 252 卷

页码：

收录情况： SCI

摘要： Sulfadimidine (SM2) is an N-substituted derivative of p-aminobenzenesulfonyl structure. This study aimed to analyze the metabolism of SM2 in carp (Cyprinus carpio). The carps were fed with SM2 at a dose of 200 mg/(kg & sdot; bw) and then killed. The blood, muscle, liver, kidney, gill, other guts, and carp aquaculture water samples were collected. The UHPLC-Q-Exactive Plus Orbitrap-MS was adopted for determining the metabolites of SM2 in the aforementioned samples. Twelve metabolites, which were divided into metabolites in vivo and metabolites in vitro, were identified using Compound Discoverer software. The metabolic pathways in vivo of SM2 in carp included acetylation, hydroxylation, glucoside conjugation, glycine conjugation, carboxylation, glucuronide conjugation, reduction, and methylation. The metabolic pathways in vitro included oxidation and acetylation. This study clarified the metabolites and metabolic pathways of SM2 in carp and provided a reference for further pharmacodynamic evaluation and use in aquaculture.

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