The epigenetic regulator Set9 harmonizes fungal development, secondary metabolism, and colonization capacity of Aspergillus flavus
文献类型： 外文期刊
第一作者： Hao, Ling
作者： Hao, Ling;Zhang, Mengjuan;Yang, Chi;Pan, Xiaohua;Wu, Dandan;Lin, Hong;Ma, Dongmei;Yao, Yanfang;Fu, Wangzhuo;Chang, Jiarui;Yang, Yanling;Zhuang, Zhenhong;Hao, Ling;Zhang, Mengjuan;Yang, Chi;Pan, Xiaohua;Wu, Dandan;Lin, Hong;Ma, Dongmei;Yao, Yanfang;Fu, Wangzhuo;Chang, Jiarui;Yang, Yanling;Zhuang, Zhenhong;Yang, Chi;Pan, Xiaohua;Ma, Dongmei
作者机构：
关键词： Aspergillus flavus; Set9; AFB 1; Histone methyltransferase; Epigenetic regulation
期刊名称：INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN： 0168-1605
年卷期： 2023 年 403 卷
页码：
收录情况： SCI
摘要： As a widely distributed food-borne pathogenic fungus, Aspergillus flavus and its secondary metabolites, mainly aflatoxin B1 (AFB1), pose a great danger to humans. It is urgent to reveal the complex regulatory network of toxigenic and virulence of this fungus. The bio-function of Set9, a SET-domain-containing histone methyltransferase, is still unknown in A. flavus. By genetic engineering means, this study revealed that, through catalyzing H4K20me2 and-me3, Set9 is involved in fungal growth, reproduction, and mycotoxin production via the orthodox regulation pathway, and regulates fungal colonization on crop kernels through adjusting fungal sensitivity reactions to oxidation stress and cell wall integrity stress. Further domain deletion and point mutation inferred that the SET domain is the core element in catalyzing H4K20 methylation, and D200 site of the domain is the key amino acid in the active center of the methyltransferase. Combined with RNA-seq analysis, this study revealed that Set9 regulates the aflatoxin gene cluster by the AflR-like protein (ALP), other than traditional AflR. This study revealed the epigenetic regulation mechanism of fungal morphogenesis, secondary metabolism, and pathogenicity of A. flavus mediated by the H4K20-methyltransferase Set9, which might provide a potential new target for early prevention of contamination of A. flavus and its deadly mycotoxins.
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