Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep

文献类型： 外文期刊

第一作者： Jia, Qi

作者： Jia, Qi;Zhang, Shuangshuang;Liu, Jianqiang;Luo, Xinhui;Liu, Yu;Li, Xin;Zhang, Lichun;Jia, Qi;Zhang, Shuangshuang;Wang, Dan;Sun, Fuliang;Xia, Guangjun

作者机构：

关键词： fibroblast growth factor 9; small-tailed Han sheep; dermal papilla cells; proliferation

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 5 期

页码：

收录情况： SCI

摘要： Fibroblast growth factor 9 (FGF9) is crucial for the growth and development of hair follicles (HFs); however, its role in sheep wool growth is unknown. Here, we clarified the role of FGF9 in HF growth in the small-tailed Han sheep by quantifying FGF9 expression in skin tissue sections collected at different periods. Moreover, we evaluated the effects of FGF9 protein supplementation on hair shaft growth in vitro and FGF9 knockdown on cultured dermal papilla cells (DPCs). The relationship between FGF9 and the Wnt/ beta-catenin signaling pathway was examined, and the underlying mechanisms of FGF9-mediated DPC proliferation were investigated. The results show that FGF9 expression varies throughout the HF cycle and participates in wool growth. The proliferation rate and cell cycle of FGF9-treated DPCs substantially increase compared to that of the control group, and the mRNA and protein expression of CTNNB1, a Wnt/beta-catenin signaling pathway marker gene, is considerably lower than that in the control group. The opposite occurs in FGF9-knockdown DPCs. Moreover, other signaling pathways are enriched in the FGF9-treated group. In conclusion, FGF9 accelerates the proliferation and cell cycle of DPCs and may regulate HF growth and development through the Wnt/beta-catenin signaling pathway.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序