Mechanistic Study of Purple Sweet Potato Anthocyanins: Multifaceted Anti-Fibrotic Effects and Targeting of PDGFRβ in Liver Fibrosis

文献类型： 外文期刊

第一作者： Dai, Jun

作者： Dai, Jun;Tian, Yuanzhi;Cheng, Chao;Yuan, Fukang;Xie, Jun;Zhang, Lidan;Wang, Xingqi;Dai, Jun;Wang, Xingqi;Li, Huansong;Gou, Lingshan;Ji, Jia;Zhang, Liming

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关键词： liver fibrosis; purple sweet potato anthocyanins; antifibrotic effects; targeted inhibition; PDGFR beta

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 50 期

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收录情况： SCI

摘要： The purple sweet potato anthocyanins (PSPA) are known for their diverse health benefits, yet their hepatoprotective effects and the mechanisms by which they combat liver fibrosis have not been thoroughly investigated. This study aimed to elucidate these effects by employing a carbon tetrachloride (CCl4)-induced mouse model of liver fibrosis. We conducted a comprehensive analysis of the effects of PSPA on liver injury, oxidative stress, inflammation, and fibrosis-related signaling pathways. Our results demonstrate that PSPA can mitigate liver damage in mice, regulate key antioxidant enzymes such as catalase and SOD, and reduce oxidative stress as indicated by lowered MDA levels. PSPA also decrease the expression of inflammatory proteins, including CD3, CD4, CD45, IL-1 beta, TNF-alpha, and IL-17A, and reduce the accumulation of fibrotic markers like type I and III collagens and alpha-SMA. Additionally, PSPA have demonstrated the ability to inhibit key fibrogenic signaling proteins, including TGF beta R2, p-Smad2, p-Smad3, p-PDGFR beta, p-AKT, p-ERK1/2, p-JNK1/2, and p-p38. Furthermore, we identified two potent monomers, PSPA-1 and PSPA-2, which directly target the PDGFR beta, a key player in fibrosis. The mechanism of action involves the inhibition of PDGF-B binding to PDGFR beta, thus disrupting the PDGF-B/PDGFR beta signaling pathway. These findings suggest that the hepatoprotective and antifibrotic effects of PSPA are due to their multifunctional bioactivities and the presence of specific active components that can effectively target fibrogenic protein.

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