Antiviral Effect of Manganese against Foot-and-Mouth Disease Virus Both in PK15 Cells and Mice

文献类型： 外文期刊

第一作者： Zhang, Zhixiong

作者： Zhang, Zhixiong;Yin, Juanbin;Zhao, Shuaiyang;Qin, Xiaodong;Chen, Fei;Yang, Yang;Bai, Ling;Wu, Yongshu;Zhang, Rui;Guo, Zijing;Li, Yanmin;Zhang, Zhidong

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关键词： foot-and-mouth disease virus; Mn2+; antiviral effect; cytokines

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 2 期

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收录情况： SCI

摘要： Foot-and-mouth disease (FMD) is an acute contagious disease of cloven-hoofed animals such as cattle, pigs, and sheep. Current emergency FMD vaccines are of limited use for early protection because their protective effect starts 7 days after vaccination. Therefore, antiviral drugs or additives are used to rapidly stop the spread of the virus during FMD outbreaks. Manganese (Mn2+) was recently found to be an important substance necessary for the host to protect against DNA viruses. However, its antiviral effect against RNA viruses remains unknown. In this study, we found that Mn2+ has antiviral effects on the FMD virus (FMDV) both in PK15 cells and mice. The inhibitory effect of Mn2+ on FMDV involves NF-kappa B activation and up-regulation of interferon-stimulated genes. Animal experiments showed that Mn2+ can be highly effective in protecting C57BL/6N mice from being infected with FMDV. Overall, we suggest Mn2+ as an effective antiviral additive for controlling FMDV infection.

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