miRNA expression analysis of the sheep follicle during the prerecruitment, dominant, and mature stages of development under FSH stimulation
文献类型： 外文期刊
第一作者： Yuan, H.
作者： Yuan, H.;Lu, J.;Xiao, S. Y.;Han, X. Y.;Song, X. T.;Yang, C. X.;Yao, Y. C.;Yuan, H.;Lu, J.;Xiao, S. Y.;Han, X. Y.;Song, X. T.;Yang, C. X.;Yao, Y. C.;Qi, M. Y.;Liu, G. S.
作者机构：
关键词： Follicular development; Ovarian steroidogenesis; FSH stimulation; miRNAs; Oxidative stress
期刊名称：THERIOGENOLOGY （ 影响因子：2.923； 五年影响因子：2.843 ）
ISSN： 0093-691X
年卷期： 2022 年 181 卷
页码：
收录情况： SCI
摘要： Follicle stimulating hormone (FSH) has been widely reported to influence ovarian follicular development, and miRNAs play a significant role in mammalian follicular development by regulating their target genes. Therefore, it is of interest to explore the roles of miRNAs in sheep follicular development during FSH stimulation. In the current study, we constructed miRNA expression profiles of small follicles (SFs, prerecruitment stage), medium follicles (MFs, dominance stage), and large follicles (LFs, maturation stage). Three and 50 significant differentially expressed miRNAs (DEMs) were identified in the MF vs. SF and LF vs. SF comparisons, respectively, and none were identified in the LF vs. MF comparison. Oar-miR10a was significantly downregulated in MFs compared with SFs. In LFs compared with SFs, miR-212-3p, miR-212-5p and miR-202-5p were significantly upregulated, and miR-27a-3p, miR-181a-5p, miR-204-5p, and miR-182-5p were significantly downregulated. Furthermore, we predicted the target genes of significant DEMs and performed functional enrichment analyses of these target genes. Analyses of KEGG pathways and GO terms showed that the putative target genes were significantly enriched in ovarian steroidogenesis, glutathione metabolism, positive regulation of cell differentiation, positive regulation of cell development, and cellular response to oxygen-containing compounds. Analyses of miRNA-gene regulatory networks suggested that miR-181a-5p-CYP11A1, (miR-27a-3p and miR-129-5p)-LDLR, (miR-212-3p and miR-212-5p)-EFNA5, (miR-181a-5p, miR-182-5p, and miR-27a-3p)-INHBA, and miR182-5p-SOD2 might be involved in follicular development. The present study provides basic data and suggests research directions for further exploration of the roles of miRNAs in sheep follicular development under FSH stimulation.(c) 2022 Published by Elsevier Inc.
分类号：
- 相关文献
作者其他论文 更多>>
-
Effects of energy restriction during growing phase on the productive performance of Hyline Brown laying hens aged 6 to 72 wk
作者：Lu, J.;Wang, Q.;Wang, K. H.;Ma, M.;Wang, X. G.;Guo, J.;Dou, T. C.;Hu, Y. P.;Li, Y. F.;Qu, L.;Lu, J.;Yang, Z.
关键词：laying hen; energy consumption during growing phase; productive performance; sexual organ development; sexual maturity
-
Rectifying cow infertility under heat stress by immunization against inhibin and supplementation of progesterone
作者：Chen, F.;Guo, R.;Guo, B.;Shi, Z.;Lu, J.;Li, W.;Mei, C.;Tsigkou, A.;Lu, J.
关键词：Immunization against inhibin; Conception rate; Hormone; Ovary; Holstein cow
-
Effects of Supplementation of Moringa Oleifera Leaf Powder on Some Reproductive Performance in Laying Hens
作者：Shen, M.;Li, T.;Lu, J.;Qu, L.;Hou, Q.;Zhang, Z.;Wu, P.;Lu, J.;Qu, L.;Wang, K.;Shen, M.
关键词：Phytogenic feed additive; clutch; follicle; endocrinology; laying hens
-
Effects of energy-restricted feeding during rearing on sexual maturation and reproductive performance of Rugao layer breeders
作者：Lu, J.;Gao, F.;Lu, J.;Li, Y. F.;Qu, L.;Wang, K. H.;Lu, J.;Ma, M.;Yang, X. D.;Shen, M. M.;Wang, X. G.;Guo, J.;Hu, Y. P.;Dou, T. C.;Li, S. M.;Yang, Z.
关键词：layer breeder; energy-restricted feeding; sexual organ development; sexual maturity; reproductive performance
-
Transcriptome analysis of sheep follicular development during prerecruitment, dominant, and mature stages after FSH superstimulation
作者：Yao, Y. C.;Song, X. T.;Zhai, Y. F.;Liu, S.;Lu, J.;Xu, X.;Zhang, J. N.;Huang, H.;Yuan, H.;Yao, Y. C.;Song, X. T.;Zhai, Y. F.;Liu, S.;Lu, J.;Xu, X.;Zhang, J. N.;Huang, H.;Yuan, H.;Qi, M. Y.;Liu, Y. F.;Liu, G. S.
关键词：RNA-seq; Ovarian steroidogenesis; Sheep; Follicular development; FSH superstimulation
-
Genome-wide association studies for mottled eggs in chickens using a high-density single-nucleotide polymorphism array
作者：Qu, L.;Shen, M. M.;Dou, T. C.;Ma, M.;Lu, J.;Wang, X. G.;Guo, J.;Hu, Y. P.;Li, Y. F.;Wang, K. H.;Shen, M. M.
关键词：Egg quality; Genomic dissection; Layer hen; Quantitative trait loci; Variance explained by single-nucleotide; polymorphism
-
Morphological and physiological characteristics of abnormal berry development in Vitis amurensis
作者：Xu, P. L.;Han, X. Y.;Ai, J.;Yang, Y. M.;Qin, H. Y.;Li, C. Y.;Liu, Y. X.;Zhao, Y.;Zhang, B. X.;Fan, S. T.;Ai, J.
关键词：Vitis amurensis; morphology; physiology; berry development
