Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish

文献类型： 外文期刊

第一作者： Xin, Shaoshuai

作者： Xin, Shaoshuai;Li, Peihai;Wang, Lizhen;Zhang, Xuanming;Zhang, Shanshan;Li, Xiaobin;Liu, Kechun;Zhang, Mengqi;Mu, Zhenqiang;Mu, Zhenqiang;Lin, Houwen

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关键词： marine-derived fungus; 4-hydroxyphenylacetic acid; antithrombotic; autophagy

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）

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年卷期： 2024 年 22 卷 4 期

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收录情况： SCI

摘要： Marine natural products are important sources of novel drugs. In this study, we isolated 4-hydroxyphenylacetic acid (HPA) from the marine-derived fungus Emericellopsis maritima Y39-2. The antithrombotic activity and mechanism of HPA were reported for the first time. Using a zebrafish model, we found that HPA had a strong antithrombotic activity because it can significantly increase cardiac erythrocytes, blood flow velocity, and heart rate, reduce caudal thrombus, and reverse the inflammatory response caused by Arachidonic Acid (AA). Further transcriptome analysis and qRT-PCR validation demonstrated that HPA may regulate autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to exert antithrombotic effects.

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