PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis

文献类型： 外文期刊

第一作者： Chu, Fengyun

作者： Chu, Fengyun;Hou, Peili;Zhu, Hongchao;Gao, Yan;Wang, Xiaomeng;Ren, Juan;Li, Min;Liu, Yu;Wang, Hongmei;Gao, Yuwei;He, Hongbin;Hou, Peili;He, Hongbin;He, Wenqi;He, Daniel Chang;Gao, Yuwei

作者机构：

关键词： PBLD; MAVS; USP4; RNA viruses; Type; IFN

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.1； 五年影响因子：10.6 ）

ISSN： 0027-8424

年卷期： 2024 年 121 卷 49 期

页码：

收录情况： SCI

摘要： Phenazine biosynthesis- like domain- containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections. We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin- specific protease transcription of USP4 via the upregulation of p53. USP4, which is a MAVS- interacting antiviral innate immunity through the p53-USP4-MAVS signaling, providing a preliminary basis for research on PBLD as a target molecule for treating RNA virus infection.

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