Refined highland barley ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and liver transcriptomics

文献类型： 外文期刊

第一作者： Wu, Tong

作者： Wu, Tong;Dai, Zijian;Luo, Yingting;Yu, Qinye;Zhang, Yiyun;Bao, Xin;Li, Rong;Shen, Qun;Xue, Yong;Wu, Tong;Dai, Zijian;Zhang, Yiyun;Bao, Xin;Li, Rong;Shen, Qun;Xue, Yong;Zhang, Yuhong;Hao, Jing;Hao, Jing

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关键词： Refined highland barley; Inflammation; Hypoglycemic effect; Gut microbiota; Liver transcriptome

期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：4.3； 五年影响因子：4.7 ）

ISSN： 1436-6207

年卷期： 2025 年 64 卷 2 期

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收录情况： SCI

摘要： PurposeIt is generally believed that refined grains lack nutritional value compared to whole grains. The objective of this study was to investigate whether refined highland barley (RHB) holds the potential to combat obesity-associated insulin resistance.MethodsThirty-two male 6-week-old C57BL/6J mice were randomly divided into four groups fed with a normal chow diet, a high-fat diet (HFD), a 30% RHB supplemented HFD diet, and a 30% whole-grain highland barley (WGHB) supplemented HFD diet. We examined the anti-obesity and anti-insulin resistance effects of RHB and compared them with WGHB in mice.ResultsRHB intervention effectively improved obesity and insulin resistance, enhanced the intestinal mucosal barrier, and reduced inflammation. Moreover, it promoted the abundance of beneficial gut bacteria such as Akkermansia, Bifidobacterium, Lachnospiraceae_NK4A136_group, Lachnospiraceae_UCG-001, Alloprevotella, and increased the production of short-chain fatty acids (SCFAs) in faeces. Additionally, RHB intervention modulated liver gene transcription, downregulating inflammatory genes like IRF3/7, STAT1/2, NLRP3, and TLR2.ConclusionsRHB could effectively alleviate obesity-related insulin resistance by targeting gut microbiota and liver transcriptomics, and its beneficial impacts are comparable to those of WGHB.

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