Biological characterization of isolated pigeon Paramyxovirus-1 and its pathogenicity analysis in SPF chickens

文献类型： 外文期刊

第一作者： Zhang, Yuxia

作者： Zhang, Yuxia;Yuan, Xiaoyuan;Yang, Jinxing;Ai, Wu;Meng, Kai;Ren, Sufang;Meng, Kai

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关键词： PPMV-1; VI; 2; 1; 2 sub-genotype; genetic characterization; pathogenicity

期刊名称：VETERINARSKI ARHIV （ 影响因子：0.5； 五年影响因子：0.6 ）

ISSN： 0372-5480

年卷期： 2023 年 93 卷 1 期

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收录情况： SCI

摘要： Pigeon paramyxovirus type 1 (PPMV-1) is considered as an antigenic variant of Newcastle Disease leading to high mortality and significant economic losses to the poultry industry. However, the pathogenicity of PPMV-1 to chickens is still unclear. Herein, we reported the biological characterization of the isolated PPMV-1 from the diseased pigeons suspected to Newcastle Disease and studied its pathogenicity in SPF chickens. The phylogenetic tree and evolution distances revealed that the new isolate belonged to a VI.2.1.1.2.2 sub-genotype of NDV. Despite the cleavage motif of the F protein containing the 112RRQKR down arrow F117 sequence associated with virulent NDV strains, and the value of MDT and ICPI of the isolate showing mesogenic characteristics, the challenge trial showed that the isolate had weak to chickens while lesions in tissues and in

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