Soft scaffold aided plasmon-enhanced upconversion luminescence and its application in vascular endothelial growth factor (VEGF) detection

文献类型： 外文期刊

第一作者： Khan, Imran Mahmood

作者： Khan, Imran Mahmood;Khan, Imran Mahmood;Niazi, Sobia;Mohsin, Ali;Zhou, You

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关键词： AuNPs; Upconversion nanoparticles; Self-assembly aptamer; VEGF; Luminescence

期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：8.4； 五年影响因子：7.2 ）

ISSN：

年卷期： 2024 年 410 卷

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收录情况： SCI

摘要： The dimensioning of glutathione-coated gold nanoparticles (GSH-Au NPs) greatly enhanced the luminescence intensity of upconversion nanoparticles (UCNPs) in close proximity and offered significant implications for biomedicine and materials science. According to systematic studies, the luminescence changes between UCNPs and AuNPs are enhanced by a well-tuned electric field-induced absorption, especially when the distance between the two is approximately 5 nm. At this distance, an upconversion enhancement factor of approximately 4.4 is achieved at a wavelength of 361 nm. This maximized plasmonic enhancement effect was subsequently employed for the quantification of Vascular Endothelial Growth Factor (VEGF) with the well-fabricated plasmon-enhanced luminescence complex (PELC) by replacing the ssDNA with the corresponding aptamer. This complex provides a basis for the rational design of a hybrid metal-upconversion complex to enhance luminescence for bioimaging and sensing applications.

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