Genome-wide analysis of Keratinibaculum paraultunense strain KD-1( T) and its key genes and metabolic pathways involved in the anaerobic degradation of feather keratin

文献类型： 外文期刊

第一作者： Wu, Weidong

作者： Wu, Weidong;Ma, Shichun;Chen, Rui;Huang, Yan;Deng, Yu;Wu, Weidong;Ma, Shichun;Chen, Rui;Huang, Yan;Deng, Yu

作者机构：

关键词： Keratinibaculum paraultunense strain KD-1( T); Genome analysis; Keratin degradation; Amino acid metabolism; Carbohydrate metabolism

期刊名称：ARCHIVES OF MICROBIOLOGY （ 影响因子：2.667； 五年影响因子：2.729 ）

ISSN： 0302-8933

年卷期： 2022 年 204 卷 10 期

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收录情况： SCI

摘要： Keratinibaculum paraultunense strain KD-1( T) (= JCM 18769( T) = DSM 26752( T)) is a strictly anaerobic rod-shaped bacterium. Under optimal conditions, feather keratin can be completely degraded by strain KD-1 within 24 h. Genomic sequencing showed that the genome was a single circular chromosome consisting of 2,307,997 base pairs (bp), with an average G + C content of 29.8% and no plasmids. A total of 2308 genes were annotated, accounting for 88.87% of the genomic sequence, and 1495 genes were functionally annotated. Among these, genes Kpa0144, Kpa0540, and Kpa0541 encoding the thioredoxin family members were identified, and may encode the potential disulfide reductases, with redox activity for protein disulfide bonds. Two potential keratinase-encoding genes, Kpa1675 and Kpa2139, were also identified, and corresponded to the ability of strain KD-1 to hydrolyze keratin. Strain KD-1 encoded genes involved in the heterotrophic metabolic pathways of 14 amino acids and various carbohydrates. The metabolic pathways for amino acid and carbohydrate metabolism were mapped in strain KD-1 based on KEGG annotations. The complete genome of strain KD-1 provided fundamental data for the further investigation of its physiology and genetics.

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