Determination of nitrofuran metabolites in fish samples by boronate affinity extraction coupled to HPLC-MS/MS using cis diol-modified mesoporous polymer (GMA-EGDMA) microspheres as adsorbents

文献类型： 外文期刊

第一作者： Huo, Wendi

作者： Huo, Wendi;Li, Jincheng;Wen, Yupeng;Zhang, Xinyuan;Liu, Huan;Mu, Yingchun;Zhang, Chaoying;Huo, Wendi;Li, Jincheng;Wen, Yupeng;Zhang, Xinyuan;Liu, Huan;Mu, Yingchun;Zhang, Chaoying;Huo, Wendi;Zhang, Rongyue;Zhao, Chunhui

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关键词： Nitrofuran metabolites; HPLC-MS/MS; Boronate affinity extraction; Fish samples

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2025 年 492 卷

页码：

收录情况： SCI

摘要： In this study, we present a simple and rapid boronate affinity extraction methodology for the HPLC-MS/MS analysis of four nitrofuran metabolites (NFMs) including SEM, AOZ, AHD and AMOZ in fish samples. To enhance the efficacy of this approach, mesoporous poly(GMA-EGDMA) microspheres, abundant in cis-diols, were synthesized for boronate affinity extraction. Meanwhile, 4-fluoro-3-formylphenyl boronic acid was utilized for the derivatization of NFMs, facilitating the immobilization of boronate ligands onto their molecular structures. Compared to the Chinese national food safety standard GB 31656.13-2021, the boronate affinity extraction eliminates the need for extraction solvents and centrifugation, streamlines the pretreatment process, and maintains a mild extraction environment. Furthermore, the poly(GMA-EGDMA) microspheres exhibited excellent reusability, retaining their performance over six adsorption-desorption cycles. The NFMs demonstrated excellent linearity (R-2 > 0.999) across the range of 0.5 to 50 mu g kg(-)(1) . The quantitative limit was established at 0.5 mu g kg(-)(1) . The recoveries of spiked tilapia samples ranged from 94.2 % to 110.7 %, while intra-day and inter-day RSDs were below 5.9 %. This method emerges as an economical, straightforward, rapid, and sensitive alternative for monitoring of NFM residues in aquatic products.

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