A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy

文献类型： 外文期刊

第一作者： Xu, Bin

作者： Xu, Bin;Deng, Jialong;Yao, Lintong;Liu, Shengbo;Hou, Hengliang;Huang, Yucheng;Zhu, Hongyuan;Wu, Shaowei;Li, Qiaxuan;Zhan, Weijie;Qiu, Hongrui;Wang, Huili;Zhou, Haiyu;Zeng, Fanjun;Zhang, Yu;Liu, Shengbo;Wu, Shaowei;Zhan, Weijie;Zhou, Haiyu;Yao, Lintong;Li, Qiaxuan;Zhou, Haiyu;Qiu, Hongrui;Wang, Huili;Zhou, Haiyu;Cao, Ziyang;Deng, Jialong;Hou, Hengliang;Zhou, Haiyu;Huang, Yucheng;Zhou, Haiyu;Xu, Bin;Yang, Xianzhu;Cao, Ziyang;Li, Yundong

作者机构：

关键词： Biomimetic nanoparticles; Membrane targeting; EGFR mutation; Tyrosine kinase inhibitor; Intracellular drug delivery; Clinical efficacy; Non -small cell lung cancer

期刊名称：BIOACTIVE MATERIALS （ 影响因子：18.9； 五年影响因子：18.9 ）

ISSN：

年卷期： 2023 年 27 卷

页码：

收录情况： SCI

摘要： The abnormal activation of epidermal growth factor receptor (EGFR) drives the development of non-small cell lung cancer (NSCLC). The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation. However, free osimertinib administration exhibits an inadequate response in vivo, with only similar to 3% patients demonstrating a complete clinical response. Consequently, we designed a biomimetic nanoparticle (CMNP@Osi) comprising a polymeric nanoparticle core and tumor cell-derived membrane-coated shell that combines membrane-mediated homologous and molecular targeting for targeted drug delivery, thereby supporting a dual-target strategy for enhancing osimertinib efficacy. After intravenous injection, CMNP@Osi accumulates at tumor sites and displays enhanced uptake into cancer cells based on homologous targeting. Osimertinib is subsequently released into the cytoplasm, where it suppresses the phosphorylation of upstream EGFR and the downstream AKT signaling pathway and inhibits the proliferation of NSCLC cells. Thus, this dual-targeting strategy using a biomimetic nanocarrier can enhance molecular-targeted drug delivery and improve clinical efficacy.

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