Polygonum sibiricum polysaccharides alleviate chronic unpredictable mild stress-induced depressive-like behaviors by regulating the gut microbiota composition and SCFAs levels

文献类型： 外文期刊

第一作者： Zhang, Yingyu

作者： Zhang, Yingyu;Sun, Yuan;Liu, Yupei;Liu, Jiameng;Sun, Jing;Bai, Yajuan;Fan, Bei;Lu, Cong;Wang, Fengzhong;Lu, Cong;Bai, Yajuan;Lu, Cong;Wang, Fengzhong;Lu, Cong;Wang, Fengzhong

作者机构：

关键词： Polygonum sibiricum polysaccharides; Depression; HPA axis; Neuroinflammation; Gut microbiota; Short -chain fatty acids

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 101 卷

页码：

收录情况： SCI

摘要： Polygonum sibiricum polysaccharides (PSP) are one of the main active components of Polygonatum sibiricum. The present study was performed to deeply explore the antidepressant-like effects of PSP on the chronic unpredictable mild stress (CUMS)-induced depression and underlying mechanisms. PSP markedly reversed the depression-like behavior and significantly increased the levels of 5-hydroxytryptamine and norepinephrine, decreased the levels of the pro-inflammatory cytokines in the hippocampus and the corticosterone and adrenocorticotropic-hormone in the serum of CUMS-induced mice. Gut microbiota dysbiosis focusing on Bacteroidetes and Firmicutes and changes of SCFAs especially for butyrate, propionate and acetate were remarkably reversed by PSP. These findings indicated that the antidepressant-like effects of PSP were related to inhibit the HPA axis hyperactivation, normalize the neurotransmitter levels, suppress the neuroinflammation, regulate the composition of gut microbiota and the levels of SCFAs. The current study provides a new insight into the potential of PSP in prevention and treatment of depression.

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