The development and application of SERS-based lateral flow immunochromatography in the field of food safety

文献类型： 外文期刊

第一作者： Liu, Wenxi

作者： Liu, Wenxi;Zhong, Wenhui;Zhang, Yichun;Gao, Xibao;Wang, Hao;Yan, Mengmeng;Zhu, Chao;Wang, Hao;Yan, Mengmeng;Zhu, Chao;Liu, Yingyue

作者机构：

关键词： SERS; Lateral flow immunoassay; Food safety; SERS-LFIA; Immune response; Raman reporting molecule

期刊名称：MICROCHIMICA ACTA （ 影响因子：5.3； 五年影响因子：4.9 ）

ISSN： 0026-3672

年卷期： 2025 年 192 卷 4 期

页码：

收录情况： SCI

摘要： Surface-Enhanced Raman Scattering-Lateral Flow Immunoassay (SERS-LFIA) inherits the advantages of simplicity, rapidness, and stability from Lateral Flow Immunoassay (LFIA), while integrating the sensitivity and accuracy of SERS, thereby attracting extensive attention in the field of food safety monitoring. This paper delves into the design strategies and principles underlying SERS-LFIA, introducing the detection formats based on SERS and contrasting the differences between traditional Raman molecules and those located in the Raman-silent region. It analyzes two immunoassay methods, namely sandwich and competitive, along with their respective applications. Importantly, by reviewing the applications of SERS-LFIA in food safety monitoring over the past 5 years, this paper summarizes the challenges faced by SERS-LFIA technology in practical applications and development. Furthermore, it provides a forward-looking perspective on the future development of SERS-LFIA. As a pivotal analytical method in the field of food safety monitoring, SERS-LFIA is demonstrating immense potential. It is hoped that this paper will offer valuable insights for the future development and application of SERS-LFIA.

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