SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants

文献类型： 外文期刊

第一作者： Ge, Linhao

作者： Ge, Linhao;Cao, Buwei;Qiao, Rui;Li, Shaofang;Shan, Hongying;Gong, Pan;Zhang, Mingzhen;Li, Hao;Zhou, Xueping;Li, Fangfang;Cui, Hongguang;Cui, Hongguang;Wang, Aiming;Wang, Aiming;Zhou, Xueping

作者机构：

关键词： SUMOylation; Pelota-Hbs1; Potyviruses

期刊名称：MOLECULAR PLANT （ 影响因子：27.5； 五年影响因子：22.6 ）

ISSN： 1674-2052

年卷期： 2023 年 16 卷 3 期

页码：

收录情况： SCI

摘要： RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals. However, it is not known whether two other RNA quality control pathways, nonstop decay and no-go decay, are capable of restricting viruses in plants. Here, we show that the evolutionarily conserved Pelota-Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae (termed potyvirids), the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide. Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron, which is conserved in almost all potyvirids. This allows Pelota to target the virus and act as a viral restriction factor. Furthermore, Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta. Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation. These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants.

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