808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy

文献类型： 外文期刊

第一作者： Liu, Ze-Yu

作者： Liu, Ze-Yu;Tang, Xiao-Yue;Huang, Chuan-Qing;Zhang, Jin;Ye, Yong;Huang, Wen-Qian;Ye, Yong

作者机构：

期刊名称：INORGANIC CHEMISTRY FRONTIERS （ 影响因子：7.779； 五年影响因子：7.154 ）

ISSN： 2052-1553

年卷期： 2022 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Antibacterial upconversion nanoparticles (UCNP)-based photodynamic-chemical combined therapy (UCNP-aPCCT) provides an ideal method to solve the problem of antibiotic-resistant bacteria in deep-tissue infections. Saponin is a kind of natural product exhibiting promising antibacterial activity. Curcumin is also a natural product that could be used as photosensitizer for antibacterial photodynamic therapy (aPDT). Herein, we have designed the dual-layer silica-coated upconversion nanoparticles combined with UCNP-photodynamic therapy (PDT) and chemotherapy using curcumin as a photosensitizer and the Camellia sapogenin derivative (CSD) as an antibacterial agent. It turned out that the prepared UCNP@mSiO(2)(Cur)@DmSiO(2)(CSD)@PVP nanoparticles displayed high antibacterial activity against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation at 808 nm. Its antibacterial activity is stronger than that of the simple sum of saponin and curcumin aPDT, indicating the existence of a synergetic photodynamic-chemical effect. The current nanoparticle drug system may have potential applications for deep-tissue anti-infection treatment.

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