Study on the mechanism of enzymatically treated mulberry (Morus atropurpurea Roxb.) leaf protein relieves liver injury in heat stress rats

文献类型： 外文期刊

第一作者： Li, Tao

作者： Li, Tao;Feng, Yuan;Li, Shaocong;Wang, Mingzhu;Zhao, Chengfeng;Zhang, Cangning;Hou, Wenyu;Shen, Manman;Zhao, Weiguo;Li, Tao;Feng, Yuan;Li, Shaocong;Wang, Mingzhu;Zhao, Chengfeng;Zhang, Cangning;Hou, Wenyu;Shen, Manman;Zhao, Weiguo;Wang, Lei;Serrano, Boris Ramos;Barcenas, Adileidys Ruiz

作者机构：

关键词： Heat stress; Enzymatically treated mulberry leaf protein; Oxidative stress; Intestinal barrier gene

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：3.8； 五年影响因子：4.6 ）

ISSN： 1756-4646

年卷期： 2024 年 119 卷

页码：

收录情况： SCI

摘要： Heat stress (HS) can lead to oxidative stress and inflammatory responses, which jeopards animal production. Enzymatically treated mulberry leaf protein (ETMLP) has antioxidant activities and immune regulation. This study aimed to investigate the impacts of ETMLP on mitigate liver injury caused by heat stress in animals. All 25 rats were divided into five groups: control, heat stress, and three ETMLP supplementation groups (HS + 0.4 %, HS + 0.8 %, and HS + 1.2 %). ETMLP supplementation effectively reduced markers of liver damage and increasing the level of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px). It also regulated protein expression associated with stress response and antioxidant defense and suppressed pro-inflammatory proteins and pathways expression. Moreover, ETMLP improved intestinal morphology and increased the intestinal barrier gene abundance. ETMLP also positively influenced the intestinal microbiota by increasing beneficial microorganisms. Overall, ETMLP reversed heat stress-induced damage, improved growth performance, and regulated the intestinal microbiota in the study animals.

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