Genome-Wide Scans for Selection Signatures in Ningxia Angus Cattle Reveal Genetic Variants Associated with Economic and Adaptive Traits

文献类型： 外文期刊

第一作者： Yin, Haiqi

作者： Yin, Haiqi;Wang, Yaxuan;Peng, Ruiqi;Wang, Yahui;Zhao, Tong;Zheng, Caihong;Xu, Lingyang;Gao, Xue;Gao, Huijiang;Li, Junya;Wang, Zezhao;Zhang, Lupei;Feng, Yuan;Wang, Yu;Jiang, Qiufei;Zhao, Jie;Zhang, Juan;Chen, Yafei

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关键词： Angus cattle; whole-genome resequencing; selection signatures; iHS; immune-related gene; economic trait

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 1 期

页码：

收录情况： SCI

摘要： The genetic improvement of beef cattle breeds is crucial for the advancement of the beef cattle industry. Whole-genome resequencing technology has been widely applied in genetic breeding as well as research on selection signatures in beef cattle. In this study, 20x whole-genome resequencing was performed on 282 Angus cattle from the Ningxia region, and a high-quality dataset encompassing extensive genomic variations across the entire genome was constructed. The iHS test identified 495 selection signal regions, which included pregnancy-associated glycoprotein (PAG) family genes and immune-related genes such as UL16-binding protein 21 (ULBP21), CD1b molecule (CD1B), and tumor necrosis factor ligand superfamily member 11 (TNFSF11). A quantitative trait locus (QTL) enrichment analysis revealed that several economic traits, including longissimus muscle area, marbling score, carcass weight, average daily gain, and milk yield, were significantly enriched in cattle with these selection signatures. Although the enrichment of QTLs for health traits was low, immune-related genes may indirectly contribute to improvements in production performance. These findings show the genetic basis of economic and adaptive traits in Ningxia Angus cattle, providing a theoretical foundation and guidance for further genetic improvement and breeding strategies.

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