Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model

文献类型： 外文期刊

第一作者： Cui, Huan

作者： Cui, Huan;Zhang, Cheng;Zhang, Chunmao;Cai, Zhuming;Chen, Zhaoliang;Guo, Zhendong;Cui, Huan;Zhao, Kui;Zhang, Cheng;Chen, Ligong;Chen, Zhaoliang;Qiao, Sina;Wang, Yingchun;Meng, Lijia;Dong, Shishan;Liu, Juxiang

作者机构：

关键词： lentinan; influenza virus; ICR mouse model; cytokine storm; TLR4; MyD88 signaling pathway

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：6.073； 五年影响因子：6.34 ）

ISSN： 2235-2988

年卷期： 2022 年 12 卷

页码：

收录情况： SCI

摘要： Influenza virus is a serious threat to global human health and public health security. There is an urgent need to develop new anti-influenza drugs. Lentinan (LNT) has attracted increasing attention in recent years. As potential protective agent, LNT has been shown to have anti-tumor, anti-inflammatory, and antiviral properties. However, there has been no further research into the anti-influenza action of lentinan in vivo, and the mechanism is still not fully understood. In this study, the anti-influenza effect and mechanism of Lentinan were studied in the Institute of Cancer Research (ICR) mouse model. The results showed that Lentinan had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice. It alleviated the pathological damage of mice infected with the influenza virus and improved blood indices. Lentinan treatment considerably inhibited inflammatory cytokine (TNF-alpha, IL-1 beta, IL-4, IL-5, IL-6) levels in the serum and lung and improved IFN-gamma cytokine levels, which reduced cytokine storms caused by influenza virus infection. The underlying mechanisms of action involved Lentinan inhibiting the inflammatory response by regulating the TLR4/MyD88 signaling pathway. This study provides a foundation for the clinical application of Lentinan, and provides new insight into the development of novel immunomodulators.

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