De novo genome assembly and analyses of 12 founder inbred lines provide insights into maize heterosis

文献类型： 外文期刊

第一作者： Wang, Baobao

作者： Wang, Baobao;Hou, Mei;Li, Xin;Li, Changyu;Zhao, Binbin;Xu, Hua;Bai, Zhijing;Xia, Zhanchao;Wang, Hai;Hou, Mei;Qi, Zhi;Shi, Junpeng;Lai, Jinsheng;Shi, Junpeng;Lai, Jinsheng;Ku, Lixia;Yao, Wen;Hou, Gege;Chen, Yanhui;Ku, Lixia;Yao, Wen;Hou, Gege;Chen, Yanhui;Li, Chunhui;Zhang, Ruyang;Sun, Xuan;Wang, Shuaishuai;Zhao, Jiuran;Li, Chunhui;Li, Yu;Wang, Tianyu;Ning, Qiang;Zhang, Zhuxin;Kong, Dexin;Wei, Hongbin;Jing, Yifeng;Dai, Zhouyan;Wang, Hu Hailing;Zhu, Xinyu;Wang, Haiyang;Dai, He;Li, Xuming;Zheng, Hongkun

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：30.8； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2023 年 55 卷 2 期

页码：

收录情况： SCI

摘要： Hybrid maize displays superior heterosis and contributes over 30% of total worldwide cereal production. However, the molecular mechanisms of heterosis remain obscure. Here we show that structural variants (SVs) between the parental lines have a predominant role underpinning maize heterosis. De novo assembly and analyses of 12 maize founder inbred lines (FILs) reveal abundant genetic variations among these FILs and, through expression quantitative trait loci and association analyses, we identify several SVs contributing to genomic and phenotypic differentiations of various heterotic groups. Using a set of 91 diallel-cross F-1 hybrids, we found strong positive correlations between better-parent heterosis of the F-1 hybrids and the numbers of SVs between the parental lines, providing concrete genomic support for a prevalent role of genetic complementation underlying heterosis. Further, we document evidence that SVs in both ZAR1 and ZmACO2 contribute to yield heterosis in an overdominance fashion. Our results should promote genomics-based breeding of hybrid maize. De novo genome assembly and analyses of 12 maize FILs provide insights into genomic and phenotypic differentiation of various heterotic groups and the molecular basis of heterosis in maize.

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