Peptide Supramolecular Hydrogels with Sustained Release Ability for Combating Multidrug-Resistant Bacteria

文献类型： 外文期刊

第一作者： Shang, Lu

作者： Shang, Lu;Liu, Jing;Wu, Yuting;Wang, Mi;Fei, Chenzhong;Liu, Yingchun;Xue, Feiqun;Zhang, Lifang;Gu, Feng;Shang, Lu;Liu, Jing;Wu, Yuting;Wang, Mi;Fei, Chenzhong;Liu, Yingchun;Xue, Feiqun;Zhang, Lifang;Gu, Feng

作者机构：

关键词： antimicrobial hydrogel; arginine end-taggingpeptides; supramolecular biomaterial; sustainedrelease; chronic wound healing

期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.5； 五年影响因子：9.6 ）

ISSN： 1944-8244

年卷期： 2023 年 15 卷 22 期

页码：

收录情况： SCI

摘要： Chronicwound infection caused by multidrug-resistant bacteriais a major threat globally, leading to high mortality rates and aconsiderable economic burden. To address it, an innovative supramolecularnanofiber hydrogel (Hydrogel-RL) harboring antimicrobial peptideswas developed based on the novel arginine end-tagging peptide (Pep6) from our recent study, triggering cross-linking. In vitro resultsdemonstrated that Hydrogel-RL can sustain the release of Pep 6 upto 120 h profiles, which is biocompatible and exhibits superior activityfor methicillin-resistant Staphylococcus aureus (MRSA) biofilm inhibition and elimination. A single treatment ofsupramolecular Hydrogel-RL on an MRSA skin infection model revealedformidable antimicrobial activity and therapeutic effects in vivo.In the chronic wound infection model, Hydrogel-RL promoted mouse skincell proliferation, reduced inflammation, accelerated re-epithelialization,and regulated muscle and collagen fiber formation, rapidly healingfull-thickness skin wounds. To show its vehicle property for woundinfection combined therapy, etamsylate, an antihemorrhagic drug, wasloaded into the porous network of Hydrogel-RL, which demonstratedimproved hemostatic activity. Collectively, Hydrogel-RL is a promisingclinical candidate agent for functional supramolecular biomaterialsdesigned for combating multidrug-resistant bacteria and rescuing stalledhealing in chronic wound infections.

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