A recombinant multi-epitope trivalent vaccine for foot-and-mouth disease virus serotype O in pigs

文献类型： 外文期刊

第一作者： Shao, Junjun

作者： Shao, Junjun;Liu, Wei;Gao, Shandian;Chang, Huiyun;Guo, Huichen

作者机构：

关键词： Foot-and-mouth disease virus (FMDV); Epitope; Vaccine; Immunization; Pig

期刊名称：VIROLOGY （ 影响因子：3.7； 五年影响因子：3.2 ）

ISSN： 0042-6822

年卷期： 2024 年 596 卷

页码：

收录情况： SCI

摘要： In order to develop a safe and effective broad-spectrum vaccine for foot-and-mouth disease (FMDV), here, we developed a recombinant FMD multiple-epitope trivalent vaccine based on three distinct topotypes of FMDV. Potency of the vaccine was evaluated by immune efficacy in pigs. The results showed that the vaccine with no less than 25 mu g of antigen elicited FMDV serotype O specific antibodies and neutralization antibodies by primarybooster regime, and offered immune protection to pigs. More importantly, the vaccine elicited not only the same level of neutralization antibodies against the three distinct topotypes of FMDV, but also provided complete protection in pigs from the three corresponding virus challenge. None of the fully protected pigs were able to generate anti-3ABC antibodies throughout the experiment, which implied the vaccine can offer sterilizing immunity. The vaccine elicited lasting-long high-level antibodies and effectively protected pigs from virulent challenge within six months of immunization. Therefore, we consider that this vaccine may be used in the future for the prevention and control of FMD.

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