Examining the wound healing potential of curcumin-infused electrospun nanofibers from polyglutamic acid and gum arabic

文献类型： 外文期刊

第一作者： Cheng, Cuilin

作者： Cheng, Cuilin;Wang, Rongchun;Ma, Jiapei;Zhang, Yingchun;Lu, Weihong;Wang, Rongchun;Zhang, Yingchun;Lu, Weihong;Cheng, Cuilin;Wang, Rongchun;Zhang, Yingchun;Lu, Weihong;Cheng, Cuilin;Jing, Qiuju;Cheng, Cuilin;Wang, Rongchun

作者机构：

关键词： Curcumin; Electrospinning dressings; Physically characterize; Antibacterial; Skin healing

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：7.7； 五年影响因子：7.7 ）

ISSN： 0141-8130

年卷期： 2024 年 267 卷

页码：

收录情况： SCI

摘要： Advancements in medicine have led to continuous enhancements and innovations in wound dressing materials, making them pivotal in medical care. We used natural biological macromolecules, gamma-polyglutamic acid and gum arabic as primary raw materials to create nanofibers laden with curcumin by blending electrostatic spinning technology in the current investigation. These nanofibers were meticulously characterized using fluorescence microscopy, scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). Our comprehensive analyses confirmed the successful encapsulation of curcumin within the nanofiber carrier and it has uniform diameter, good water absorption and mechanical properties. Subsequently, we evaluated the antimicrobial effects of these curcumin-loaded nanofibers against Staphylococcus aureus through an oscillating flask method. We created a mouse model with acute fullthickness skin defects to further investigate the wound healing potential. We conducted various biochemical assays to elucidate the mechanism of action. The results revealed that curcumin nanofibers profoundly impacted wound healing. They bolstered the expression of TGF-beta 1 and VEGF and reduced the expression of inflammatory factors, leading to an accelerated re-epithelialization process, enhanced wound contraction, and increased regeneration of new blood vessels and hair follicles. Furthermore, these nanofibers positively influenced the proportion of three different collagen types. This comprehensive study underscores the remarkable potential of curcumin-loaded nanofibers to facilitate wound healing and lays a robust experimental foundation for developing innovative, natural product-based wound dressings.

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