Egg white composition, antioxidant capacity, serum and yolk lipids and oxidative damage of the oviduct magnum in laying hens fed diets contaminated with different concentrations of cadmium

文献类型： 外文期刊

第一作者： Zhu, Mingkun

作者： Zhu, Mingkun;Yan, Ming;Li, Muwang;Zhu, Mingkun;Yan, Ming;Li, Muwang;Li, Huaiyu;Zou, Xiaoting

作者机构：

关键词： Cadmium; oviduct magnum; egg white; lipid; laying hens

期刊名称：ITALIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.5； 五年影响因子：2.4 ）

ISSN： 1594-4077

年卷期： 2023 年 22 卷 1 期

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收录情况： SCI

摘要： Total of 384 healthy 38-week-old hens were randomly divided into four treatments. Layers in four groups were fed a basal diet and a basal diet with Cd at the level of 15, 30 and 60 mg/kg for nine weeks. Results showed that Cd could dose-dependently deposited in magnum and a positive correlation occurred between the accumulation of Cd in magnum and Cd content in egg whites. When compared with control group, 60 mg/kg Cd decreased magnum ovomucin, ovalbumin, lysozyme and ovomucoid gene expressions, but increased avidin gene expression obviously. Hens receiving 60 mg/kg Cd exhibited a significant decrease in egg white ovalbumin content and its proportion in total protein and increase in total cholesterol and LDLC levels in serum and yolk. The level of GSH and activities of T-SOD and CAT in magnum and GSH-Px activity in egg white were decreased significantly, while MDA level in both magnum and egg white was increased obviously in 60 mg/kg Cd group. Besides, Cd induced oxidative stress, inflammation, endoplasmic reticulum stress (ERS) and mitophagy accompanied by a significant up-regulation of the expressions of Keap1, IL1 beta, TNF alpha, NF-kappa B, p65, p-p65, Grp78, CHOP, ATF4, ATF6, IRE1 alpha, Grp94, PINK1, Parkin, Fundc1, GRP75, VDAC1, MCU, MFF, Bnip3 and LC3I/II and a significant down-regulation of the expressions of Nrf2, HO-1, SOD1, SOD2, SOD3, MFN1, MFN2 and PGC1 alpha. These results indicated that Cd can increase serum and yolk cholesterol level and induce magnum oxidative stress, inflammation, ERS and mitophagy through Nrf2/NF-kappa B and IRE1 alpha/IP3R/GRP75/VDAC1/MCU pathways, thus disrupting egg white composition.

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