Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood

文献类型： 外文期刊

第一作者： Yang, Mingxing

作者： Yang, Mingxing;Xu, Guowei;Zhang, Jingyan;Guo, Zhiting;Wang, Lei;Li, Jianxi;Sun, Yan;Liang, Chao;Zhou, Yuxia;Li, Yajun;Ru, Yi;Wang, Xuezhi

作者机构：

关键词： feline; IFN-omega; extracellular vesicles; miRNA; antiviral effects

期刊名称：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH （ 影响因子：2.3； 五年影响因子：2.9 ）

ISSN： 1079-9907

年卷期： 2024 年 44 卷 3 期

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收录情况： SCI

摘要： Feline interferon omega (IFN-omega) has been proven to have high antiviral activity; however, its in-depth antiviral effects remain unknown. Extracellular vesicles (EVs) have been demonstrated to participate in the regulation of the immune response pathway for the body through various active substances, especially through the microRNA (miRNA) carried by them. In this study, we isolated EVs from feline peripheral blood by differential centrifugation, and further found that the content of IFN-omega in EVs increased continuously within 24 h after IFN-omega treatment, and a large number of miRNAs were significantly downregulated in EVs within 12 h after IFN-omega treatment. These significantly differentially expressed miRNAs were important for regulating changes in antiviral cytokines. This study reveals for the first time the correlation between EVs-mediated miRNA in feline peripheral blood and IFN-omega on antiviral immune response, which may provide strong data support for the development of novel antiviral nanomedicine and the research of the antiviral effects of IFN-omega.

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