Fabrication, characterization, and dihydromyricetin-loaded bioavailability of Pickering emulsions stabilized by Ampelopsis grossedentata polysaccharide -fish collagen peptide composite nanoparticles

文献类型： 外文期刊

第一作者： Pan, Haihui

作者： Pan, Haihui;Wang, Feilin;Sheng, Yuanhao;Kong, Fansheng;Pan, Haihui;Jiao, Wenjuan;Zhang, Yousheng

作者机构：

关键词： Fish collagen peptide; Ampelopsis grossedentata polysaccharide; Nanocomplexes; Pickering emulsion; Bioavailability

期刊名称：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS （ 影响因子：4.9； 五年影响因子：4.7 ）

ISSN： 0927-7757

年卷期： 2024 年 701 卷

页码：

收录情况： SCI

摘要： A novel strategy was devised to synthesize robust nanocarriers by conjugating fish collagen peptides (FCP) with Ampelopsis grossedentata polysaccharide (AGP), culminating in the creation of FCP-AGP nanoparticles (FCAGPs) for advanced drug delivery systems. The innovative approach entailed the systematic investigation of particle size, zeta potential, and surface hydrophobicity alterations in FCAGPs upon varying AGP concentrations. The optimized FCAGP-4 nanoparticles, boasting a precisely engineered AGP content of 2.0 % (w/v) and an average particle diameter finely tuned to 353.2 +/- 10.5 nm, demonstrated outstanding characteristics in dispersibility, stability, and emulsifying capacity. Furthermore, the water contact angle of FCAGP nanoparticles notably increased from 46.3 +/- 2.8 degrees to 70.2 +/- 5.6 degrees, indicating enhanced surface hydrophobicity. The mechanism by which FCAGP nanoparticles were attached to the surface of oil droplets to stabilize the emulsions was elucidated by confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). Significantly, a modified sample pretreatment technique was employed to demonstrate clearly the emulsion phase interface on the SEM.Innovative FCAGP-stabilized Pickering emulsions achieved 65.39 % in DMY bioavailability, facilitating its slow-release and enhanced bioaccessibility during in vitro digestion. Pickering emulsions loaded DMY demonstrated improved stability and sustained release under simulated digestive conditions, bolstering its therapeutic efficacy. Our findings solidify the theoretical basis for green synthesis of propeptide-polysaccharide nanoparticles and introduce a novel strategy for targeted propeptide Pickering emulsions in drug delivery, highlighting the transformative potential of FCAGP nanoparticles in enhancing lipophilic drug bioavailability and pharmacological impact.

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