Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?

文献类型： 外文期刊

第一作者： He, Zuyong

作者： He, Zuyong;Chen, Yaosheng;Mei, Gui;Li, Ning

作者机构：

关键词： transgene: expression;therapeutic recombinant protein: expression;GenBank sequence data;protein tertiary structure;tissue specific codon usage pattern

期刊名称：TRANSGENIC RESEARCH （ 影响因子：2.788； 五年影响因子：2.377 ）

ISSN：

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收录情况： SCI

摘要： Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression.

分类号： R394

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