Theabrownin ameliorated lipid accumulation via modulating circadian rhythms in oleic acid-induced HepG2 cells
文献类型： 外文期刊
第一作者： Zhao, Chunyan
作者： Zhao, Chunyan;Zhao, Lei;Li, Zelin;Lei, Shuwen;Shan, Bo;Wang, Qiuping;Tan, Chao;Gong, Jiashun;Li, Zelin;Gong, Jiashun;Peng, Chunxiu;Miao, Yue
作者机构： Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China;Yunnan Acad Agr Sci, Agroprod Proc Res Inst, Kunming 650221, Peoples R China;Yunnan Agr Univ, Coll Hort & Landscape, Kunming 650201, Yunnan, Peoples R China;Yunnan Acad Agr Sci, Med Plants Res Inst, Kunming 650201, Yunnan, Peoples R China
关键词： Pu-erh tea; Theabrownin; Circadian rhythms; Lipid accumulation; Proteomics; siRNA; HepG2 cells
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 2023影响因子：3.8； 五年影响因子：4.6 ）
ISSN： 1756-4646
年卷期： 2024 年 116 卷
收录情况： SCI
摘要： Theabrownin (TB) is the main characteristic component and bioactive substance of Pu-erh tea. Our previous studies have demonstrated interactions among the TB, the circadian rhythm, and obesity, but the underlying mechanism remains unclear. In this study, we focused on the mechanism by which TB ameliorates lipid accumulation caused by oleic acid (OA) by modulating circadian rhythm genes in HepG2 cells. The results showed that TB could reduce triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) levels, reactive oxygen species (ROS) overproduction and lipid droplet formation. Additionally, TB could regulate OAmediated circadian desynchrony by regulating the mRNA and protein expression of circadian genes. Furthermore, as revealed by proteomics results, the PPAR pathway is a potential pathway through which TB ameliorates lipid metabolism disorders. After Bmal1 knockdown, the ameliorative effect of TB on OA-induced PPAR gamma and plin1 protein expression was decreased, which suggested that TB could ameliorate lipid accumulation in HepG2 cells via a Bmal1-dependent pathway.
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