Enhancing Genomic Prediction Accuracy in Beef Cattle Using WMGBLUP and SNP Pre-Selection

文献类型： 外文期刊

第一作者： Zhao, Huqiong

作者： Zhao, Huqiong;Xie, Xueyuan;Zhang, Yuanqing;Niu, Xiaoyan;Zhao, Huqiong;Xie, Xueyuan;Ma, Haoran;Xu, Lingyang;Gao, Huijiang;Li, Junya;Wang, Zezhao;Zhou, Peinuo;Xu, Boran

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关键词： GWAS; beef cattle; multi-population genomic prediction; simulation

期刊名称：AGRICULTURE-BASEL （ 影响因子：3.6； 五年影响因子：3.8 ）

ISSN：

年卷期： 2025 年 15 卷 10 期

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收录情况： SCI

摘要： Genomic selection (GS) plays a crucial role in livestock breeding. However, its implementation in Chinese beef cattle breeding is constrained by a limited reference population and incomplete data records. To address these challenges, this study aimed to identify more effective models for multi-population genomic selection. We simulated five different beef cattle populations and selected three populations with varying levels of kinship to investigate the impact of population relationships on genomic prediction. Utilizing results from a genome-wide association study (GWAS), we preselected different proportions of single nucleotide polymorphism (SNP). Subsequently, we employed three models-genomic best linear unbiased prediction (GBLUP), multi-genomic best linear unbiased prediction (MGBLUP), and weighted multi-genomic best linear unbiased prediction (WMGBLUP)-for within-population and multi-population genomic prediction. Our results showed that increasing the size of the training set improved within-population prediction accuracy. Furthermore, both MGBLUP and WMGBLUP outperformed GBLUP in terms of prediction accuracy for both within-population and multi-population analyses. Among the models evaluated, the WMGBLUP model, which utilized the top 5% of preselected SNPs based on GWAS findings, demonstrated superior performance, yielding an improvement of up to 11.1% in within-population prediction and 16.5% in multi-population prediction. In summary, both WMGBLUP and MGBLUP models exhibit enhanced efficacy in improving genomic prediction accuracy, and the incorporation of GWAS results can further optimize their performance.

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