A VQ-motif-containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism

文献类型： 外文期刊

第一作者： Hao, Zeyun

作者： Hao, Zeyun;Fang, Hong;Fang, Liang;Xu, Xiao;He, Feng;You, Xiaoman;Wang, Debao;Wang, Ruyi;Ning, Yuese;Tian, Jinfu;Li, Shaoya;Xia, Lanqin;Fang, Hong;Du, Qiang;Chen, Qiuhong;Xie, Wenya;Zuo, Shimin;Yuan, Meng;Wang, Guo-Liang;Xia, Lanqin

作者机构：

期刊名称：CELL REPORTS （ 影响因子：9.995； 五年影响因子：10.99 ）

ISSN： 2211-1247

年卷期： 2022 年 40 卷 7 期

页码：

收录情况： SCI

摘要： Rice blast and bacterial blight, caused by the fungus Magnaporthe oryzae and the bacterium Xanthomonas oryzae pv. oryzae (Xoo), respectively, are devastating diseases affecting rice. Here, we report that a rice valine-glutamine (VQ) motif-containing protein, OsVQ25, balances broad-spectrum disease resistance and plant growth by interacting with a U-Box E3 ligase, OsPUB73, and a transcription factor, OsWRKY53. We show that OsPUB73 positively regulates rice resistance against M. oryzae and Xoo by interacting with and promoting OsVQ25 degradation via the 26S proteasome pathway. Knockout mutants of OsVQ25 exhibit enhanced resistance to both pathogens without a growth penalty. Furthermore, OsVQ25 interacts with and suppresses the transcriptional activity of OsWRKY53, a positive regulator of plant immunity. OsWRKY53 downstream defense-related genes and brassinosteroid signaling genes are upregulated in osvq25 mutants. Our findings reveal a ubiquitin E3 ligase-VQ protein-transcription factor module that fine-tunes plant immunity and growth at the transcriptional and posttranslational levels.

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