The mechanisms of hydroxy-a-sanshool from Zanthoxyum bungeanum maxim activates AMPK-HIF1-PKM2 pathway to fix the obesity

文献类型： 外文期刊

第一作者： Ren, Tingyuan

作者： Ren, Tingyuan;Xu, Fangyan;Qin, Likang;Zhu, Yuping;Zhao, Degang;Zhao, Degang;Zhao, Degang;Lu, Mintao;Zhao, Degang

作者机构：

关键词： Zanthoxylum bungeanum; Hydroxy-& alpha;-sanshool; High-fat diet; Lipid metabolism; Oxidative stress

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 107 卷

页码：

收录情况： SCI

摘要： To explore effects of hydroxy-a-sanshool (HAS) on metabolism disorder and oxidative stress induced by high-fat diet. The 50 SD male rats were divided into normal group (NC), high-fat group (MC) and HAS groups. Some key indexes, metabolites and signaling molecules were determined. The results showed that compared with MC, HAS significantly reduced body weight, contents of TC, TG, LDL-C, HIF-1, ATP, LDH, CPT and CS in liver; increased activity of SOD and CAT in liver and serum. The identified 7 differential metabolites by UPLC/HRMS were enriched to 18 metabolic pathways including ascorbate metabolism, glutathione metabolism, HIF-1 and glucagon pathway. Furtherly, Western blot showed that increased protein abundance of p-AMPK, p-ACC, Nrf2 and HO-1; reduced that of HIF-1a, p-PKM2 (Tyr105) and CPT1A in HAS groups. It was indicated that HAS activates AMPK-HIF1-PKM2 pathway and Nrf2/HO1 pathway to reduce oxidative damage and improve lipid and energy metabolism disorder caused by high-fat diet.

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