Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2/HO-1 pathway

文献类型： 外文期刊

第一作者： Wan, Fan

作者： Wan, Fan;Hou, Fujiang;Cai, Xueying;Wan, Fan;Wang, Mengyu;Chen, Liang;Zhong, Ruqing;Liu, Lei;Yi, Bao;Zhang, Hongfu

作者机构：

关键词： Chlorogenic acid; Colitis; Gut barrier; Inflammatory responses; Nrf-2; HO-1

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.908 ）

ISSN： 1756-4646

年卷期： 2021 年 87 卷

页码：

收录情况： SCI

摘要： Chlorogenic acid (CGA) is an important source of phenolic acids with multiple health functions such as antioxidation, anti-inflammation, and free radical scavenging effects. This study aimed to investigate whether the nuclear factor erythroid 2-related factor 2 (Nrf-2)/HO-1 pathway played a role in CGA ameliorating DSS-induced colitis in mice. 500 mg/kg CGA (high chlorogenic acid, HCGA) and 250 mg/kg CGA (low chlorogenic acid, LCGA) supplementation could alleviate the symptoms of colitis and the related mechanisms. qPCR results indicated that HCGA treatment dramatically upregulated mRNA expression levels of anti-inflammatory cytokine, antioxidative enzymes, occluding, and Nrf-2/HO-1 pathway downstream targets. Western blot results proved that HCGA supplementation significantly upregulated HO-1 level. Besides, Spearman's correlation analysis showed that the colon mRNA expression levels of antioxidative enzymes had a positive correlation with Nrf-2/ HO-1 pathway downstream targets. Collectively, CGA supplementation could effectively ameliorate DSS-induced colitis by activating the Nrf-2/HO-1 pathway to suppress oxidative stress and inflammatory responses, and promoting gut barrier.

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