Environmental level of bisphenol F induced reproductive toxicity toward zebrafish

文献类型： 外文期刊

第一作者： Mu, Xiyan

作者： Mu, Xiyan;Liu, Jia;Wang, Hui;Yuan, Lilai;Huang, Ying;Li, Yingren;Qi, Suzhen;Qian, Le;Wang, Chengju;Li, Tiejun;Guo, Yuanming

作者机构：

关键词： Bisphenol F; Environmental concentrations; Fecundity disorder; Gonadal impairment; Abnormal offspring development

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）

ISSN： 0048-9697

年卷期： 2022 年 806 卷

页码：

收录情况： SCI

摘要： Bisphenol F (BPF), as an important bisphenol A substitute, is being increasingly used for industrial production. Here we performed large scale fecundity test for zebrafish that are continuous exposed to environmental levels of BPF (0.5, 5 and 50 mu g/L) from embryonic stage, and identified suppressed spawning capacity of females and reduced fertility rate of males in adulthood. Although pathological change is only observed in female gonads, the transcriptional change in the hypothalamic-pituitary-gonad axis genes occurred in the gonads of both female and male fish at 150 days post-exposure. F1 generation embryos showed abnormal developmental outcomes in-cluding decreased heart rate, reduced body length, and inhibition of spontaneous movement after parental expo -sure to BPF. RNA-sequencing showed that the genes involved in skeletal/cardiac muscle development were significantly altered in F1 embryos spawned by BPF-treated zebrafish. The advanced pathway analysis showed that cancer and tumour formation were the most enriched pathways in the offspring of 0.5 and 5.0 mu g/L groups; organismal development and cardiovascular system development were mainly affected after parental exposure to 50 mu g/L of BPF; these changes were mediated by several involved regulators such as GATA4, MYF6, and MEF2C. These findings confirmed that long-term exposure to BPF at environment relevant concentration would result in reproductive toxicity among zebrafish indicating the urgent demand for the control of BPA substitutes. (c) 2021 Elsevier B.V. All rights reserved.

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[1]Environmental level of bisphenol F induced reproductive toxicity toward zebrafish. Mu, Xiyan,Liu, Jia,Wang, Hui,Yuan, Lilai,Huang, Ying,Li, Yingren,Qi, Suzhen,Qian, Le,Wang, Chengju,Li, Tiejun,Guo, Yuanming. 2022

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